Killing via IgA but Not IgG Fc Receptors Immature Neutrophils Mediate Tumor Cell
نویسندگان
چکیده
منابع مشابه
Chimeric IgA antibodies against HLA class II effectively trigger lymphoma cell killing.
Antibodies against human leukocyte antigen (HLA) class II, such as 1D10 or Lym-1, are currently being evaluated for the treatment of B-cell lymphomas. Previous studies have demonstrated that, in addition to IgG Fc receptors, the human myeloid IgA receptor (Fc(alpha)RI, CD89) also effectively triggered tumor cell killing. Therefore, we used the variable light and heavy chain sequences from anoth...
متن کاملColostral neutrophils express Fca receptors (CD89) lacking g chain association and mediate noninflammatory properties of secretory IgA
Colostrum plays an important role in protecting newborn infants against acute gastrointestinal and respiratory infections. IgA antibodies have been considered the major effector component; however, the role of their receptors on colostral phagocytes, especially neutrophils, has not been studied. Here, we demonstrate that CD15 colostrum neutrophils express IgA Fc receptors (FcaR, CD89) at levels...
متن کاملSimultaneous exposure to FcγR and FcαR on monocytes and macrophages enhances antitumor activity in vivo
Therapeutic antibodies are effective for tumor immunotherapy and exhibit prominent clinical effects. All approved antibody therapeutics utilize IgG as the molecular format. Antibody-dependent cell-mediated cytotoxicity (ADCC) is a key mechanism for tumor cell killing by antibodies. For IgG antibodies, ADCC depends on FcγR-expressing cells, such as natural killer (NK) cells. However, in patients...
متن کاملImmunoglobulins cytophilic for human lymphocytes, monocytes, and neutrophils.
The cytophilic activity of human myeloma proteins of different classes and subclasses for lymphocytes, monocytes, and neutrophils was investigated. Binding of both unaggregated immunoglobulins (Ig) and Ig aggregated with rabbit F(ab)2 anti-Fab fragment sera was determined. Lymphocytes bound unaggregated IgG1 and IgG3 proteins, but none of the proteins of the other classes. In contrast, after ag...
متن کاملA monoclonal antibody specific for immunoglobulin A receptor triggers polymorphonuclear neutrophil superoxide release.
An immunoglobulin M (IgM) monoclonal antibody, My43, specific for IgA Fc receptor (Fc alpha R) on human monocytes, bound to human polymorphonuclear neutrophils (PMNs) and inhibited their ability to bind IgA but not IgG. It was observed that the PMN oxidative burst was induced by both polymeric IgA and aggregated IgG, whereas IgM was without effect. The IgG-mediated oxidative burst was inhibited...
متن کامل